Conventional antibiotics generally must enter the bacterial cell to
interact with their biochemical target. Bacteria generally can
develop resistance one of two ways:
• Efflux --- pump out the foreign chemical which has crossed
through the cell membrane; or
• Target mutation --- because of rapid reproduction, bacteria
change the structure of the biochemical target
PMX-30063 mimics host defense proteins in that it does not
have to enter the cell. It directly disrupts the bacterial cell membrane
from the outside - sidestepping bacteria’s own resistance
methods (efflux and target mutation) - which makes bacterial
resistance unlikely to develop.
Source: http://irgnews.com/sites/default/themes/publisher/images/companies/PYMX/PYMX_fs.pdf
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